Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity
Identifieur interne : 005223 ( Main/Exploration ); précédent : 005222; suivant : 005224Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity
Auteurs : Marta Derecka [États-Unis] ; Agnieszka Gornicka [États-Unis] ; Sergei B. Koralov [États-Unis] ; Karol Szczepanek [États-Unis] ; Magdalena Morgan [États-Unis] ; Vidisha Raje [États-Unis] ; Jennifer Sisler [États-Unis] ; Qifang Zhang [États-Unis] ; Dennis Otero [États-Unis] ; Joanna Cichy [Pologne] ; Klaus Rajewsky [États-Unis] ; Kazuya Shimoda [Japon] ; Valeria Poli ; Birgit Strobl [Autriche] ; Sandra Pellegrini [France] ; Thurl E. Harris [États-Unis] ; Patrick Seale [États-Unis] ; Aaron P. Russell [Australie] ; Andrew J. Mcainch [Australie] ; Paul E. O Rien [Australie] ; Susanna R. Keller [États-Unis] ; Colleen M. Croniger [États-Unis] ; Tomasz Kordula [États-Unis] ; Andrew C. Larner [États-Unis]Source :
- Cell metabolism [ 1550-4131 ] ; 2012.
Abstract
Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high fat diet and in obese humans. Expression of Tyk2 or the constitutively active form of the transcription factor Stat3 (CAStat3) restores differentiation in Tyk2−/− brown preadipocytes. Furthermore, Tyk2−/− mice expressing CAStat3 transgene in BAT also show improved BAT development, normal levels of insulin and significantly lower body weights. Stat3 binds to PRDM16, a master regulator of BAT differentiation, and enhances the stability of PRDM16 protein. These results define Tyk2 and Stat3 as critical determinants of brown fat-lineage and suggest that altered levels of Tyk2 are associated with obesity in both rodents and humans.
Url:
DOI: 10.1016/j.cmet.2012.11.005
PubMed: 23217260
PubMed Central: 3522427
Affiliations:
- Australie, Autriche, France, Japon, Pologne, États-Unis
- Californie, Massachusetts, Ohio, Virginie, État de New York
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001E27
- to stream Pmc, to step Curation: 001C83
- to stream Pmc, to step Checkpoint: 001D27
- to stream Ncbi, to step Merge: 001057
- to stream Ncbi, to step Curation: 001057
- to stream Ncbi, to step Checkpoint: 001057
- to stream Main, to step Merge: 005421
- to stream Main, to step Curation: 005223
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity</title><author><name sortKey="Derecka, Marta" sort="Derecka, Marta" uniqKey="Derecka M" first="Marta" last="Derecka">Marta Derecka</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Gornicka, Agnieszka" sort="Gornicka, Agnieszka" uniqKey="Gornicka A" first="Agnieszka" last="Gornicka">Agnieszka Gornicka</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Immunology Cleveland Clinic Foundation, Cleveland, OH 44195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology Cleveland Clinic Foundation, Cleveland, OH 44195</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Koralov, Sergei B" sort="Koralov, Sergei B" uniqKey="Koralov S" first="Sergei B." last="Koralov">Sergei B. Koralov</name><affiliation wicri:level="2"><nlm:aff id="A3">New York University Medical School, Department of Pathology, New York, NY 10016</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York University Medical School, Department of Pathology, New York</wicri:cityArea></affiliation></author><author><name sortKey="Szczepanek, Karol" sort="Szczepanek, Karol" uniqKey="Szczepanek K" first="Karol" last="Szczepanek">Karol Szczepanek</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Morgan, Magdalena" sort="Morgan, Magdalena" uniqKey="Morgan M" first="Magdalena" last="Morgan">Magdalena Morgan</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Raje, Vidisha" sort="Raje, Vidisha" uniqKey="Raje V" first="Vidisha" last="Raje">Vidisha Raje</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Sisler, Jennifer" sort="Sisler, Jennifer" uniqKey="Sisler J" first="Jennifer" last="Sisler">Jennifer Sisler</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Zhang, Qifang" sort="Zhang, Qifang" uniqKey="Zhang Q" first="Qifang" last="Zhang">Qifang Zhang</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Otero, Dennis" sort="Otero, Dennis" uniqKey="Otero D" first="Dennis" last="Otero">Dennis Otero</name><affiliation wicri:level="2"><nlm:aff id="A4">Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cichy, Joanna" sort="Cichy, Joanna" uniqKey="Cichy J" first="Joanna" last="Cichy">Joanna Cichy</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Rajewsky, Klaus" sort="Rajewsky, Klaus" uniqKey="Rajewsky K" first="Klaus" last="Rajewsky">Klaus Rajewsky</name><affiliation wicri:level="2"><nlm:aff id="A6">Program in Cellular and Molecular Medicine, Children Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Cellular and Molecular Medicine, Children Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shimoda, Kazuya" sort="Shimoda, Kazuya" uniqKey="Shimoda K" first="Kazuya" last="Shimoda">Kazuya Shimoda</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University</wicri:regionArea><wicri:noRegion>Miyazaki University</wicri:noRegion></affiliation></author><author><name sortKey="Poli, Valeria" sort="Poli, Valeria" uniqKey="Poli V" first="Valeria" last="Poli">Valeria Poli</name><affiliation><nlm:aff id="A8">Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center University of Turin, Via Nizza 52, 10126 Torino Italy</nlm:aff><wicri:noCountry code="subfield">10126 Torino Italy</wicri:noCountry></affiliation></author><author><name sortKey="Strobl, Birgit" sort="Strobl, Birgit" uniqKey="Strobl B" first="Birgit" last="Strobl">Birgit Strobl</name><affiliation wicri:level="1"><nlm:aff id="A9">Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna</wicri:regionArea><wicri:noRegion>University of Veterinary Medicine Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Pellegrini, Sandra" sort="Pellegrini, Sandra" uniqKey="Pellegrini S" first="Sandra" last="Pellegrini">Sandra Pellegrini</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Immunology, Institut Pasteur, 25, 28 rue du Docteur Roux 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Institut Pasteur, 25, 28 rue du Docteur Roux 75724 Paris</wicri:regionArea><wicri:noRegion>75724 Paris</wicri:noRegion><wicri:noRegion>75724 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Thurl E" sort="Harris, Thurl E" uniqKey="Harris T" first="Thurl E." last="Harris">Thurl E. Harris</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22903</wicri:regionArea><wicri:noRegion>22903</wicri:noRegion></affiliation></author><author><name sortKey="Seale, Patrick" sort="Seale, Patrick" uniqKey="Seale P" first="Patrick" last="Seale">Patrick Seale</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Aaron P" sort="Russell, Aaron P" uniqKey="Russell A" first="Aaron P." last="Russell">Aaron P. Russell</name><affiliation wicri:level="1"><nlm:aff id="A13">Centre of Physical Activity and Nutrition (C-PAN) Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, 3125, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre of Physical Activity and Nutrition (C-PAN) Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, 3125</wicri:regionArea><wicri:noRegion>3125</wicri:noRegion></affiliation></author><author><name sortKey="Mcainch, Andrew J" sort="Mcainch, Andrew J" uniqKey="Mcainch A" first="Andrew J." last="Mcainch">Andrew J. Mcainch</name><affiliation wicri:level="1"><nlm:aff id="A14">Biomedical and Lifestyle Diseases (BioLED) Unit, School of Biomedical and Health Sciences, Victoria University, St Albans, 3021, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical and Lifestyle Diseases (BioLED) Unit, School of Biomedical and Health Sciences, Victoria University, St Albans, 3021</wicri:regionArea><wicri:noRegion>3021</wicri:noRegion></affiliation></author><author><name sortKey="O Rien, Paul E" sort="O Rien, Paul E" uniqKey="O Rien P" first="Paul E." last="O Rien">Paul E. O Rien</name><affiliation wicri:level="1"><nlm:aff id="A15">Centre for Obesity Research and Education (CORE), Monash University, The Alfred Hospital, Melbourne, 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Obesity Research and Education (CORE), Monash University, The Alfred Hospital, Melbourne, 3004</wicri:regionArea><wicri:noRegion>3004</wicri:noRegion></affiliation></author><author><name sortKey="Keller, Susanna R" sort="Keller, Susanna R" uniqKey="Keller S" first="Susanna R." last="Keller">Susanna R. Keller</name><affiliation wicri:level="2"><nlm:aff id="A16">Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Croniger, Colleen M" sort="Croniger, Colleen M" uniqKey="Croniger C" first="Colleen M." last="Croniger">Colleen M. Croniger</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Nutrition, Case Western University School of Medicine Cleveland, OH 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Case Western University School of Medicine Cleveland, OH 44106</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kordula, Tomasz" sort="Kordula, Tomasz" uniqKey="Kordula T" first="Tomasz" last="Kordula">Tomasz Kordula</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Larner, Andrew C" sort="Larner, Andrew C" uniqKey="Larner A" first="Andrew C." last="Larner">Andrew C. Larner</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23217260</idno><idno type="pmc">3522427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522427</idno><idno type="RBID">PMC:3522427</idno><idno type="doi">10.1016/j.cmet.2012.11.005</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001E27</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E27</idno><idno type="wicri:Area/Pmc/Curation">001C83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C83</idno><idno type="wicri:Area/Pmc/Checkpoint">001D27</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001D27</idno><idno type="wicri:Area/Ncbi/Merge">001057</idno><idno type="wicri:Area/Ncbi/Curation">001057</idno><idno type="wicri:Area/Ncbi/Checkpoint">001057</idno><idno type="wicri:doubleKey">1550-4131:2012:Derecka M:tyk:and:stat</idno><idno type="wicri:Area/Main/Merge">005421</idno><idno type="wicri:Area/Main/Curation">005223</idno><idno type="wicri:Area/Main/Exploration">005223</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity</title><author><name sortKey="Derecka, Marta" sort="Derecka, Marta" uniqKey="Derecka M" first="Marta" last="Derecka">Marta Derecka</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Gornicka, Agnieszka" sort="Gornicka, Agnieszka" uniqKey="Gornicka A" first="Agnieszka" last="Gornicka">Agnieszka Gornicka</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Immunology Cleveland Clinic Foundation, Cleveland, OH 44195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology Cleveland Clinic Foundation, Cleveland, OH 44195</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Koralov, Sergei B" sort="Koralov, Sergei B" uniqKey="Koralov S" first="Sergei B." last="Koralov">Sergei B. Koralov</name><affiliation wicri:level="2"><nlm:aff id="A3">New York University Medical School, Department of Pathology, New York, NY 10016</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York University Medical School, Department of Pathology, New York</wicri:cityArea></affiliation></author><author><name sortKey="Szczepanek, Karol" sort="Szczepanek, Karol" uniqKey="Szczepanek K" first="Karol" last="Szczepanek">Karol Szczepanek</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Morgan, Magdalena" sort="Morgan, Magdalena" uniqKey="Morgan M" first="Magdalena" last="Morgan">Magdalena Morgan</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Raje, Vidisha" sort="Raje, Vidisha" uniqKey="Raje V" first="Vidisha" last="Raje">Vidisha Raje</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Sisler, Jennifer" sort="Sisler, Jennifer" uniqKey="Sisler J" first="Jennifer" last="Sisler">Jennifer Sisler</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Zhang, Qifang" sort="Zhang, Qifang" uniqKey="Zhang Q" first="Qifang" last="Zhang">Qifang Zhang</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Otero, Dennis" sort="Otero, Dennis" uniqKey="Otero D" first="Dennis" last="Otero">Dennis Otero</name><affiliation wicri:level="2"><nlm:aff id="A4">Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cichy, Joanna" sort="Cichy, Joanna" uniqKey="Cichy J" first="Joanna" last="Cichy">Joanna Cichy</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Rajewsky, Klaus" sort="Rajewsky, Klaus" uniqKey="Rajewsky K" first="Klaus" last="Rajewsky">Klaus Rajewsky</name><affiliation wicri:level="2"><nlm:aff id="A6">Program in Cellular and Molecular Medicine, Children Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Cellular and Molecular Medicine, Children Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shimoda, Kazuya" sort="Shimoda, Kazuya" uniqKey="Shimoda K" first="Kazuya" last="Shimoda">Kazuya Shimoda</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University</wicri:regionArea><wicri:noRegion>Miyazaki University</wicri:noRegion></affiliation></author><author><name sortKey="Poli, Valeria" sort="Poli, Valeria" uniqKey="Poli V" first="Valeria" last="Poli">Valeria Poli</name><affiliation><nlm:aff id="A8">Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center University of Turin, Via Nizza 52, 10126 Torino Italy</nlm:aff><wicri:noCountry code="subfield">10126 Torino Italy</wicri:noCountry></affiliation></author><author><name sortKey="Strobl, Birgit" sort="Strobl, Birgit" uniqKey="Strobl B" first="Birgit" last="Strobl">Birgit Strobl</name><affiliation wicri:level="1"><nlm:aff id="A9">Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna</wicri:regionArea><wicri:noRegion>University of Veterinary Medicine Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Pellegrini, Sandra" sort="Pellegrini, Sandra" uniqKey="Pellegrini S" first="Sandra" last="Pellegrini">Sandra Pellegrini</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Immunology, Institut Pasteur, 25, 28 rue du Docteur Roux 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Institut Pasteur, 25, 28 rue du Docteur Roux 75724 Paris</wicri:regionArea><wicri:noRegion>75724 Paris</wicri:noRegion><wicri:noRegion>75724 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Thurl E" sort="Harris, Thurl E" uniqKey="Harris T" first="Thurl E." last="Harris">Thurl E. Harris</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22903</wicri:regionArea><wicri:noRegion>22903</wicri:noRegion></affiliation></author><author><name sortKey="Seale, Patrick" sort="Seale, Patrick" uniqKey="Seale P" first="Patrick" last="Seale">Patrick Seale</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Aaron P" sort="Russell, Aaron P" uniqKey="Russell A" first="Aaron P." last="Russell">Aaron P. Russell</name><affiliation wicri:level="1"><nlm:aff id="A13">Centre of Physical Activity and Nutrition (C-PAN) Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, 3125, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre of Physical Activity and Nutrition (C-PAN) Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, 3125</wicri:regionArea><wicri:noRegion>3125</wicri:noRegion></affiliation></author><author><name sortKey="Mcainch, Andrew J" sort="Mcainch, Andrew J" uniqKey="Mcainch A" first="Andrew J." last="Mcainch">Andrew J. Mcainch</name><affiliation wicri:level="1"><nlm:aff id="A14">Biomedical and Lifestyle Diseases (BioLED) Unit, School of Biomedical and Health Sciences, Victoria University, St Albans, 3021, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical and Lifestyle Diseases (BioLED) Unit, School of Biomedical and Health Sciences, Victoria University, St Albans, 3021</wicri:regionArea><wicri:noRegion>3021</wicri:noRegion></affiliation></author><author><name sortKey="O Rien, Paul E" sort="O Rien, Paul E" uniqKey="O Rien P" first="Paul E." last="O Rien">Paul E. O Rien</name><affiliation wicri:level="1"><nlm:aff id="A15">Centre for Obesity Research and Education (CORE), Monash University, The Alfred Hospital, Melbourne, 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Obesity Research and Education (CORE), Monash University, The Alfred Hospital, Melbourne, 3004</wicri:regionArea><wicri:noRegion>3004</wicri:noRegion></affiliation></author><author><name sortKey="Keller, Susanna R" sort="Keller, Susanna R" uniqKey="Keller S" first="Susanna R." last="Keller">Susanna R. Keller</name><affiliation wicri:level="2"><nlm:aff id="A16">Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Croniger, Colleen M" sort="Croniger, Colleen M" uniqKey="Croniger C" first="Colleen M." last="Croniger">Colleen M. Croniger</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Nutrition, Case Western University School of Medicine Cleveland, OH 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Case Western University School of Medicine Cleveland, OH 44106</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kordula, Tomasz" sort="Kordula, Tomasz" uniqKey="Kordula T" first="Tomasz" last="Kordula">Tomasz Kordula</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Larner, Andrew C" sort="Larner, Andrew C" uniqKey="Larner A" first="Andrew C." last="Larner">Andrew C. Larner</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><series><title level="j">Cell metabolism</title><idno type="ISSN">1550-4131</idno><idno type="eISSN">1932-7420</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high fat diet and in obese humans. Expression of Tyk2 or the constitutively active form of the transcription factor Stat3 (CAStat3) restores differentiation in Tyk2−/− brown preadipocytes. Furthermore, Tyk2−/− mice expressing CAStat3 transgene in BAT also show improved BAT development, normal levels of insulin and significantly lower body weights. Stat3 binds to PRDM16, a master regulator of BAT differentiation, and enhances the stability of PRDM16 protein. These results define Tyk2 and Stat3 as critical determinants of brown fat-lineage and suggest that altered levels of Tyk2 are associated with obesity in both rodents and humans.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>France</li><li>Japon</li><li>Pologne</li><li>États-Unis</li></country><region><li>Californie</li><li>Massachusetts</li><li>Ohio</li><li>Virginie</li><li>État de New York</li></region></list><tree><noCountry><name sortKey="Poli, Valeria" sort="Poli, Valeria" uniqKey="Poli V" first="Valeria" last="Poli">Valeria Poli</name></noCountry><country name="États-Unis"><region name="Virginie"><name sortKey="Derecka, Marta" sort="Derecka, Marta" uniqKey="Derecka M" first="Marta" last="Derecka">Marta Derecka</name></region><name sortKey="Croniger, Colleen M" sort="Croniger, Colleen M" uniqKey="Croniger C" first="Colleen M." last="Croniger">Colleen M. Croniger</name><name sortKey="Gornicka, Agnieszka" sort="Gornicka, Agnieszka" uniqKey="Gornicka A" first="Agnieszka" last="Gornicka">Agnieszka Gornicka</name><name sortKey="Harris, Thurl E" sort="Harris, Thurl E" uniqKey="Harris T" first="Thurl E." last="Harris">Thurl E. Harris</name><name sortKey="Keller, Susanna R" sort="Keller, Susanna R" uniqKey="Keller S" first="Susanna R." last="Keller">Susanna R. Keller</name><name sortKey="Koralov, Sergei B" sort="Koralov, Sergei B" uniqKey="Koralov S" first="Sergei B." last="Koralov">Sergei B. Koralov</name><name sortKey="Kordula, Tomasz" sort="Kordula, Tomasz" uniqKey="Kordula T" first="Tomasz" last="Kordula">Tomasz Kordula</name><name sortKey="Larner, Andrew C" sort="Larner, Andrew C" uniqKey="Larner A" first="Andrew C." last="Larner">Andrew C. Larner</name><name sortKey="Morgan, Magdalena" sort="Morgan, Magdalena" uniqKey="Morgan M" first="Magdalena" last="Morgan">Magdalena Morgan</name><name sortKey="Otero, Dennis" sort="Otero, Dennis" uniqKey="Otero D" first="Dennis" last="Otero">Dennis Otero</name><name sortKey="Raje, Vidisha" sort="Raje, Vidisha" uniqKey="Raje V" first="Vidisha" last="Raje">Vidisha Raje</name><name sortKey="Rajewsky, Klaus" sort="Rajewsky, Klaus" uniqKey="Rajewsky K" first="Klaus" last="Rajewsky">Klaus Rajewsky</name><name sortKey="Seale, Patrick" sort="Seale, Patrick" uniqKey="Seale P" first="Patrick" last="Seale">Patrick Seale</name><name sortKey="Sisler, Jennifer" sort="Sisler, Jennifer" uniqKey="Sisler J" first="Jennifer" last="Sisler">Jennifer Sisler</name><name sortKey="Szczepanek, Karol" sort="Szczepanek, Karol" uniqKey="Szczepanek K" first="Karol" last="Szczepanek">Karol Szczepanek</name><name sortKey="Zhang, Qifang" sort="Zhang, Qifang" uniqKey="Zhang Q" first="Qifang" last="Zhang">Qifang Zhang</name></country><country name="Pologne"><noRegion><name sortKey="Cichy, Joanna" sort="Cichy, Joanna" uniqKey="Cichy J" first="Joanna" last="Cichy">Joanna Cichy</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Shimoda, Kazuya" sort="Shimoda, Kazuya" uniqKey="Shimoda K" first="Kazuya" last="Shimoda">Kazuya Shimoda</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Strobl, Birgit" sort="Strobl, Birgit" uniqKey="Strobl B" first="Birgit" last="Strobl">Birgit Strobl</name></noRegion></country><country name="France"><noRegion><name sortKey="Pellegrini, Sandra" sort="Pellegrini, Sandra" uniqKey="Pellegrini S" first="Sandra" last="Pellegrini">Sandra Pellegrini</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Russell, Aaron P" sort="Russell, Aaron P" uniqKey="Russell A" first="Aaron P." last="Russell">Aaron P. Russell</name></noRegion><name sortKey="Mcainch, Andrew J" sort="Mcainch, Andrew J" uniqKey="Mcainch A" first="Andrew J." last="Mcainch">Andrew J. Mcainch</name><name sortKey="O Rien, Paul E" sort="O Rien, Paul E" uniqKey="O Rien P" first="Paul E." last="O Rien">Paul E. O Rien</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005223 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005223 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3522427
|texte= Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23217260" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |